DETERx™ Advantages

DETERx™ and COL‐003 represent a very attractive product opportunity based on the following factors:

• DETERx™ represents "best in class" technology with potential for valuable product differentiation opportunity

• Strong intellectual property position with issued patents that expire in 2025

• Large and growing market opportunity for oral ER opioids with a significant unmet medical need

• Late stage product opportunity with significant near term revenue potential

• Fast Track Status granted by the FDA,

• DETERx™ Platform able to create portfolio of tamper-resistant ER products